Sloan, a 50-year-old male, suffers from cirrhosis of the liver. He was admitted to the hospital with jaundice and ascites. The doctor prescribed spironolactone to alleviate the ascites.
1. Where in the nephron will this drug act, and on what cells?
2. How does the drug alleviate ascites? Be specific.
3. How did cirrhosis cause Sloan’s jaundice and ascites? Use all anatomical terminology and be specific.